Indices of multilocus linkage disequilibrium


Linkage disequilibrium is an ubiquitous biological phenomenon. However a common metric for disequilibrium — the index of association or IA – is dependent on sample size. In this paper we present a modification of IA that removes this dependency. This method has been implemented in a software package.


Agapow & Burt (2001) Molecular Ecology Notes 1:101–102